Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a 10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
Nosocomial infections may be best treated by which of the following agents?
I- Cephalosporin 3rd generation
II- Macrolides antibiotics
III- Penicillins
All of the following are examples of quinolone antimicrobial agents, EXCEPT
Drug used together with chloroquine in the treatment of malaria with the purpose to kill persistants parasites in the liver of a person infected with Plasmodium vivax is:
Which of the following agents would be used in the treatment of infections caused by Helicobacter pylori as combination therapy?
Drug of choice in the treatment of percutaneous blood infection-schistosomyasis may include:
Which of the following agents may interfere with the regular effect of penicillins?
Drugs used in the treatment of meningitis are all of the following, EXCEPT:
Common etiologic agents of community-acquired pneumonia include:
I Escherichia coli
II Haemophilus influenzae
III Mycoplasma pneumoniae
Which of the following is considered the FIRST precursor of vitamin A formation?
Identify the correct pathway of blood flow from the small intestine to the liver:
Which of the following vitamin has its chemical structure related to PABA?
Gamma aminobutyric acid (GABA. is:
I the major inhibitory neurotransmitter in the brain
II found primarily in interneurons
III synthesized from glycine
Autoimmune disorders include which of the following?
I Graves' disease
II Systemic Lupus Erythematosus
III Osteoarthritis
Organisms commonly implicated in the cause of Traveller's Diarrhea include:
I Bacteroides fragilis
II Escherichia coli
III Shigella sp
Which of the following factors would be important in determining the concentration of drug that would be reached in the cerebrospinal fluid for treatment of meningitis?
I Oil/water partition coefficient
II Binding to plasma protein
III pKa of the drug
The fraction of bound receptors in a well-defined drug-receptor binding system is determined by:
I the equilibrium drug-receptor dissociation constant
II the free drug concentration
III the total receptor concentration
Which financial statement could be used to determine the total value of prescription drug sales for a pharmacy during the course of a year?
Allopurinol, xanthine oxidase inhibitor, used in gout treatment may produce all the following side effects, EXCEPT:
Correct administration of Penicillamine in the treatment of rheumatois arthritis include:
In an adequately powered, randomized controlled trial conducted over 3 years, a specific serious side effect (i.e. reduction in leukocytes) with conventional therapy is seen in 0.5% of the study sample. In patients who receive a newly discovered drug, only 0.45% experience the same side effect. Based on these results, the minimum number of patients that would have to receive the new drug for 3 years to statistically demonstrate the prevention of one episode of this side effect in at least one patient is:
Chronic progressive lower airway destruction causing reduced pulmonary inspiration and expiratory capacity is known as:
Calcitonin is mainly classified as hormone liberated by thyroid gland. Which stimulate the release of calcitonin?